| AHRQ | Agency for Healthcare Research and Quality |
| ANSI | American National Standards Institute |
| ARRA | American Recovery and Reinvestment Act |
| BA | Business Associate |
| BAA | Business Associate Agreement |
| CAH | Critical Access Hospital |
| CCHIT | Certification Commission for Health Information Technology |
| CDC | Centers for Disease Control and Prevention |
| CE | Covered Entity |
| CER | Comparative Effectiveness Research |
| CFR | Code of Federal Regulations |
| CGD | Certification Guidance Document |
| CHPL | Certified Health Information Technology Products List |
| CMS | Center for Medicare and Medicaid Services |
| CORE | Committee on Operating Rules for Information Exchange |
| DURSA | Data Use and Reciprocal Support Agreement |
| EHR | Electronic Health Record |
| FQHC | Federally Qualified Health Centers |
| FTC | Federal Trade Commission |
| HCCN | Health Center Controlled Networks |
| HHS | Department of Health and Human Services |
| HIE | Health Information Exchange |
| HIOs | Health Information Exchange Organizations |
| HIPAA | Health Insurance Portability and Accountability Act |
| HIT | Health Information Technology |
| HITECH | Health Information Technology for Economic and Clinical Health Act |
| HITRC | Health Information Technology Research Center |
| HRSA | Health Resources and Services Administration |
| IFR | Interim Final Rule |
| ISO | International Organization for Standardization |
| MU | Meaningful Use |
| NHIN | Nationwide Health Information Network [now NW-HIN] |
| NHITI | National Health Information Technology Infrastructure |
| NIH | National Institutes of Health |
| NIST | National Institute for Standards and Technology |
| NPRM | Notice of Proposed Rule-Making |
| NTDC | National Training and Dissemination Center |
| NW-HIN | Nationwide Health Information Network Center [formerly NHIN] |
| OCR | Office of Civil Rights (Dept. of Health and Human Services) |
| ONC | Office of the National Coordinator for Health Information Technology [also referred to as ONCHIT] |
| ONC-ACB | ONC-Authorized Certification Body |
| ONC-ATCB | ONC-Authorized Testing and Certification Body |
| PHI | Protected Health Information |
| PHR | Personal Health Record |
| RECs | Health Information Technology Regional Extension Centers |
| SDE | State Designated Entity |
| SDO | Standards Development Organization |
| SHARP | Strategic Health IT Advanced Research Projects |
| SSA | Social Security Act |